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KMID : 1161520220260040137
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Animal Cells and Systems
2022 Volume.26 No. 4 p.137 ~ p.147
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Neuro-immune interactions at single-cell resolution in neurodevelopmental, infectious, and neurodegenerative diseases
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Park Hyun-Jung
Jung Ho-Sung
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Abstract
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Recent technological advance in single-cell and single-nucleus transcriptomics has made it possible to generate an unprecedentedly detailed landscape of neuro-immune interactions in healthy and diseased brains. In this review, we overview the recent literature that catalogs single-cell-level gene expression in brains with signs of inflammation, focusing on maternal immune activation, viral infection, and auto-immune diseases. The literature also includes a series of papers that provide strong evidence for immunological contributions to neurodegenerative diseases, which, in a strict sense, are not considered neuroinflammatory. To help with the discussion, we present a diagram of experimental and analytical flows in the single-cell analysis of the brain. We also discuss the recurring themes of neuro-immune interactions and suggest future research directions.
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KEYWORD
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Single-cell RNA sequencing, COVID-19, multiple sclerosis, Alzheimer’s disease, Parkinson’s disease
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